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An antigenic variant of the Hong Kong/68 influenza A 2 virus

Published online by Cambridge University Press:  15 May 2009

Marguerite S. Pereira  and
G. C. Schild
Marguerite S. Pereira
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
G. C. Schild
Affiliation:
World Influenza Centre, National Institute for Medical Research, Mill Hill, London, N.W. 7
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Summary

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Both the haemagglutinin and the neuraminidase of influenza A 2 virus have undergone progressive antigenic drift since this subtype first appeared in 1957.

In 1968 a strain showing a much greater antigenic difference was isolated in Hong Kong. This variant has been responsible for epidemics throughout the world in the past 2 years.

In the second year of its prevalence a small proportion of strains isolated showed a small but definite antigenic change, related principally to the haemagglutinin component.

This new variant formed about 4 % of all strains investigated and was detected in Britain, Portugal, France and New Zealand.

Information

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 1 , March 1971 , pp. 99 - 103
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Coleman, M. T., Dowdle, W. R., Pereira, H. G., Schild, G. C. & Chang, W. K. (1968). The Hong Kong/68 influenza A 2 variant. Lancet ii, 1384.CrossRefGoogle Scholar
Isaacs, A., Hart, R. J. C. & Law, V. G. (1962). Influenza viruses 1957–60. Bulletin of the World Health Organization 26, 253.Google ScholarPubMed
Morris, J. A., Hatano, M., Robinson, R. Q., Aulisio, C. G. & Smadel, J. E. (1963). Antigenic relationship of 1961–1963 A2 influenza viruses to prototype A2 1957 strains. Proceedings of the Society for Experimental Biology and Medicine 114, 406.CrossRefGoogle Scholar
Pereira, H. G., Pereira, M. S. & Law, V. G. (1964). Antigenic variants of influenza A2 virus. Bulletin of the World Health Organization 31, 129.Google ScholarPubMed
Schild, G. C. & Newman, R. W. (1969 a). Antibody against influenza A2 neuraminidase in human sera. Journal of Hygiene 67, 353.CrossRefGoogle ScholarPubMed
Schild, G. C. & Newman, R. W. (1969 b). Immunological relationships between the neuraminidases of human and animal influenza A viruses. Bulletin of the World Health Organization 41, 437.Google Scholar
Schulman, J. L. & Kilbourne, E. D. (1969). The antigenic relationship of the neuraminidase of Hong Kong virus to that of other human strains of influenza A virus. Bulletin of the World Health Organization 41, 425.Google ScholarPubMed
Webster, R. C. & Laver, W. G. (1967). Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. Journal of Immunology 99, 49.CrossRefGoogle Scholar
Weinberger, H. L., Buescher, E. L., Mccown, J. & Gauld, J. R. (1963). Antigenic variation of recently isolated A 2 influenza viruses. Proceedings of the Society for Experimental Biology and Medicine 114, 413.CrossRefGoogle Scholar