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Association Between Health-Related Quality of Life and Willingness of COVID-19 Vaccination: A Cross-sectional Study in China

Published online by Cambridge University Press:  22 August 2025

Jingrui Wang ,
Ruihan Xi ,
Zhenzhen Su ,
Yijin Feng ,
Yujun Fan ,
Wanmin Su ,
Jing Xia ,
Qianwen Pan ,
Lina Shi  and
YuanFang Li
...Show all authors
Jingrui Wang
Affiliation:
School of Medicine, Henan Kaifeng College of Science Technology and Communication, Kaifeng, China Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Ruihan Xi
Affiliation:
School of Medicine, Kaifeng University, Kaifeng, 475004, China Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Zhenzhen Su
Affiliation:
Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China
Yijin Feng
Affiliation:
School of Medicine, Henan Kaifeng College of Science Technology and Communication, Kaifeng, China Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Yujun Fan
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Wanmin Su
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Jing Xia
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Qianwen Pan
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Lina Shi
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
YuanFang Li
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Bo Li
Affiliation:
Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
Peixi Wang*
Affiliation:
School of Pharmacy, Guangzhou Huali College, Guangzhou, Guangdong, China Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University, Kaifeng, China
*
Corresponding author: Peixi Wang; Email: peixi001@163.com
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Abstract

Objectives

This study aims to explore the association between Health-Related Quality of Life (HRQoL) and people’s willingness to receive the coronavirus disease 2019 (COVID-19) vaccination.

Methods

This survey was conducted in November 2020. 1461 participants (convenient sampling method) completed the online questionnaire. HRQoL was assessed using the 12-item Short Form Survey (SF-12) which included Physical and Mental Component Summary (PCS and MCS). The relationship between HRQoL and the willingness of COVID-19 vaccination was assessed by multivariate logistic regression.

Results

25.67% of respondents intended to be vaccinated immediately, 61.05% hesitated, and 13.28% refused. The mean score of PCS was 51.27 ± 6.30 and MCS was 47.72 ± 9.26. The multivariate logistic regression analysis showed the correlation between HRQoL and the willingness of vaccination (Ρ<0.05). Based on Z-score standardization, for 1 standard deviation (SD) increase in PCS, the odds ratio (OR) was 0.854 (95% confidence interval [CI]: 0.753-0.969) for hesitant vaccination vs. immediate vaccination. For 1 SD increase in MCS, the OR was 0.810 (95% CI: 0.677-0.970) for reluctant vaccination (refusal of COVID-19 vaccination) vs immediate vaccination, and the OR was 0.808 (95% CI: 0.710-0.919) for hesitant vaccination vs immediate vaccination.

Conclusions

People with better HRQoL preferred to receive the COVID-19 vaccine immediately.

Keywords

Health-Related Quality of Life (HRQoL)willingnessCOVID-19 vaccination12-item Short Form Survey (SF-12)

Information

Type
Original Research
Information
Disaster Medicine and Public Health Preparedness , Volume 19 , 2025 , e244
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Society for Disaster Medicine and Public Health, Inc

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