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Weight loss supplement causing acute heart block in a child

Part of: Electrophysiology

Published online by Cambridge University Press:  06 January 2020

Daniel R. O’Brien Open the ORCID record for Daniel R. O’Brien [Opens in a new window] ,
Vivian Szymczuk  and
Cecilia A. Albaro
Daniel R. O’Brien*
Affiliation:
Department of Internal Medicine/Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
Vivian Szymczuk
Affiliation:
Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
Cecilia A. Albaro
Affiliation:
Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
*
Author for correspondence: Daniel R. O’Brien, OSF St. Francis Medical Center, Department of Internal Medicine/Pediatrics, University of Illinois College of Medicine at Peoria, 530 NE Ave, Peoria, IL61604, USA. Tel: +1 309-655-3863; E-mail: daniel.obrien04@gmail.com
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Abstract

A 16-year-old male was admitted to the paediatric ICU with acute onset of vomiting, somnolence, and chest pain, and electrocardiogram showing 2nd degree heart block after ingesting an Aleurites moluccana (Candlenut) seed as a herbal weight loss supplement. Electrocardiogram showed progressively worsening heart block with down-sloping of the ST segments, resembling digoxin toxicity. After 2 days of ICU observation, his symptoms began to improve and eventually resolved. The side effects of herbal supplements are often unknown but by analysing cases such as these, physicians can develop a better understanding of these substances to help guide management.

Keywords

Candlenutherbal supplementheart block

Information

Type
Brief Report
Information
Cardiology in the Young , Volume 30 , Issue 1 , January 2020 , pp. 131 - 133
Copyright
© Cambridge University Press 2020

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References

Moffett, B, Garner, A, Zapata, T, Orcutt, J, Niu, M, Lopez, K. Serum digoxin concentrations and clinical signs and symptoms of digoxin toxicity in the paediatric population. Cardiol Young 2016; 26: 493–498. doi:10.1017/S1047951115000505CrossRefGoogle ScholarPubMed
Gonzalez-Stuart, A, Rivera, JO. Toxicity of candlenut seed (Aleurites moluccanus), a purported herbal weight loss supplement. Pharmacologia 2017; 8: 25–31. doi:10.5567/pharmacologia.2017.25.31Google Scholar
Centre for Agriculture and Bioscience Design. Invasive Species Compendium. Aleurites moluccana (candlenut tree). Retrieved February 19, 2019, from https://www.cabi.org/isc/datasheet/4124.Google Scholar
Nelson, LS, Shih, RD, Balick, MJ. Handbook of Poisonous and Injurious Plants, 2nd edn. The New York Botanical Garden, New York, NY, 2007.Google Scholar
Mahmmoud, YA, Christensen, SB. Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. Biochim Biophys Acta (BBA) – Biomembr, Published July 13, 2011. Retrieved July 4, 2019, from https://www.sciencedirect.com/science/article/pii/S0005273611002033?via=ihub.CrossRefGoogle Scholar