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Severe hyperlactatemia from Warburg effect due to post-transplant lymphoproliferative disorder after paediatric heart transplantation with resolution following thiamine administration

Published online by Cambridge University Press:  21 May 2025

Michael J. Martinez Open the ORCID record for Michael J. Martinez [Opens in a new window] ,
Hannah St. Francis ,
Gloria Contreras Yametti ,
Rana Biary  and
Rakesh K. Singh
Michael J. Martinez*
Affiliation:
Department of Pediatrics, Division of Cardiology, NYU Grossman School of Medicine, New York, NY, USA
Hannah St. Francis
Affiliation:
Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA
Gloria Contreras Yametti
Affiliation:
Department of Pediatrics, Division of Cardiology, NYU Grossman School of Medicine, New York, NY, USA
Rana Biary
Affiliation:
Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA
Rakesh K. Singh
Affiliation:
Department of Pediatrics, Division of Cardiology, NYU Grossman School of Medicine, New York, NY, USA
*
Corresponding author: Michael Martinez; Email: michaelj.martinez@nyulangone.org
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Abstract

Hyperlactatemia is a common and concerning finding in the paediatric cardiac ICU as it may signify tissue hypoperfusion and/or hypoxia. However, it is important to include other aetiologies for an elevated lactate in the differential, especially when the lactate is significantly elevated (> 8 mmol/L). We present the case of metabolic acidosis with severe hyperlactatemia secondary to Warburg effect and presumed thiamine deficiency in a paediatric heart transplant patient with post-transplant lymphoproliferative disorder.

Keywords

Lymphoproliferative disorderWarburg effectoncologicthiaminepaediatricscardiology

Information

Type
Case Report
Information
Cardiology in the Young , Volume 35 , Issue 6 , June 2025 , pp. 1287 - 1289
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Copyright
© The Author(s), 2025. Published by Cambridge University Press

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