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More lessons learned from the Pediatric Heart Transplant Study*

Published online by Cambridge University Press:  17 September 2015

Yuk M. Law
Yuk M. Law*
Affiliation:
Division of Pediatric Cardiology, Seattle Children’s Hospital, Seattle, Washington, United States of America Division of Pediatric Cardiology, University of Washington, Seattle, Washington, United States of America
*
Correspondence to: Y. M. Law, Division of Pediatric Cardiology, Seattle Children’s Hospital and University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, United States of America. Tel: +206 987 4233; Fax: +206 987 3839; E-mail: yuk.law@seattlechildrens.org
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Abstract

Paediatric heart transplantation has evolved over the last 3 decades. The research group, Pediatric Heart Transplant Study, has been in step with that evolution over the nearly 20 years of its existence by utilising its registry to contribute a wealth of clinical research to the field. The highlights of its studies will be presented in this review.

Keywords

Heart transplantationchildrenpediatricsregistry

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Footnotes

*

Presented at Johns Hopkins All Children’s Heart Institute, International Pediatric Heart Failure Summit, Saint Petersburg, Florida, United States of America, 4–5 February, 2015.

References

1. Kantrowics, A. America’s first human heart transplantation: the concept, the planning, and the furor. ASAIO J 1998; 44: 244–252.CrossRefGoogle Scholar
2. Mendelhoff, EN. The history of pediatric heart and lung transplantation. Pediatr Transplant 2002; 6: 270–279.CrossRefGoogle Scholar
3. Chinnock, RE, Bailey, LL. Heart transplantation for congenital heart disease in the first year. Curr Cardiol Rev 2011; 7: 72–84.CrossRefGoogle ScholarPubMed
4. Hsu, D, Naftel, D, Webber, S, et al. Lessons learned from the pediatric heart transplant study. Congenit Heart Dis 2006; 1: 54–62.CrossRefGoogle ScholarPubMed
5. Dipchand, A, Kirk, R, Mahle, W, et al. Ten years of pediatric heart transplantation: a report from the pediatric heart transplant study. Pediatr Transplant 2013; 17: 99–111.CrossRefGoogle Scholar
6. McGiffin, D, Naftel, D, Kirklin, J, et al. Predicting outcome after listing for heart transplantation in children: comparison of Kaplan-Meier and parametric competing risk analysis. J Heart Lung Transplant 1997; 16: 713–722.Google ScholarPubMed
7. Shaddy, R, Naftel, D, Boyle, G, et al. Outcome of cardiac transplantation in children: survival in a contemporary multi-institutional experience and the pediatric heart transplant study. Circulation 1996; 94 (Suppl II): 69–73.Google Scholar
8. Canter, C, Naftel, D, Caldwell, R, et al. Survival and risk factors for death after cardiac transplantation in infants: a multi-institutional study. Circulation 1997; 96: 227–231.CrossRefGoogle ScholarPubMed
9. Lamour, J, Kanter, K, Naftel, D, et al. The effect of age, diagnosis, and previous surgery in children and adults undergoing heart transplantation for congenital heart disease. J Am Coll Cardiol 2009; 7: 160–165.CrossRefGoogle Scholar
10. Bernstein, D, Naftel, D, Chin, C, et al. Outcome of listing for cardiac transplantation for failed Fontan: a multi-institutional study. Circulation 2006; 25: 273–280.CrossRefGoogle Scholar
11. Mahle, W, Tresler, M, Edens, E, et al. Allosensitization and outcomes in pediatric heart transplantation. J Heart Lung Transplant 2011; 30: 1221–1227.CrossRefGoogle ScholarPubMed
12. Chrisant, MRK, Naftel, DC, Drummond-Webb, J, et al. Fate of infants with hypoplastic left heart syndrome listed for cardiac transplantation: a multi-center study. J Heart Lung Transplant 2005; 24: 576–582.CrossRefGoogle Scholar
13. Everitt, M, Boyle, G, Schechtman, K, et al. Early survival after heart transplant in young infants is lowest after failed single-ventricle palliation: a multi-institutional study. J Heart Lung Transplant 2012; 31: 509–516.CrossRefGoogle ScholarPubMed
14. Guleserian, K, Schechtman, K, Zheng, J, et al. Outcomes following listing for primary transplantation for infants with unoperated Non-Hypoplastic Left Heart Syndrome (Non-HLHS) congenital heart disease: a multi-institutional study. J Heart Lung Transplant 2011; 30: 1023–1032.CrossRefGoogle Scholar
15. Morrow, R, Naftel, D, Chinnock, R, et al. Outcome of listing for heart transplantation in infants younger than six months: predictors of death and interval to transplantation. J Heart Lung Transplant 1997; 16: 1255–1266.Google ScholarPubMed
16. Kirklin, J, Naftel, D, Pearce, F, et al. Should status II patients be removed from the pediatric heart transplant waiting list? A multi-institutional study. J Heart Lung Transplant 2006; 25: 271–275.CrossRefGoogle ScholarPubMed
17. Singh, T, Sleeper, L, Lipshultz, S, et al. Association of left ventricular dilation at listing for heart transplant with post-listing and early post-transplant mortality in children with dilated cardiomyopathy. Circulation 2009; 28: 591–598.Google Scholar
18. Dipchand, A, Naftel, D, Feingold, B, et al. Outcomes of children with cardiomyopathy listed for transplant: a multi-institutional study. J Heart Lung Transplant 2009; 28: 1312–1321.CrossRefGoogle ScholarPubMed
19. Gajarski, R, Naftel, D, Pahl, E, et al. Outcomes of pediatric patients with hypertrophic cardiomyopathy listed for transplant. J Heart Lung Transplant 2009; 28: 1329–1334.CrossRefGoogle ScholarPubMed
20. Zangwill, S, Naftel, S, L’Ecuyer, T, et al. Outcomes of children with restrictive cardiomyopathy listed for heart transplant: a multi-institutional study. J Heart Lung Transplant 2009; 28: 1335–1340.CrossRefGoogle ScholarPubMed
21. Pietra, B, Kantor, P, Bartlett, H, et al. Early predictors of survival to and after heart transplantation in children with dilated cardiomyopathy. Circulation 2012; 126: 1079–1086.CrossRefGoogle ScholarPubMed
22. Blume, E, Naftel, D, Bastardi, H, Duncan, B, Kirklin, J, Webber, S. Outcomes of children bridged to heart transplantation with ventricular assist devices: a multi-institutional study. Circulation 2006; 113: 2313–2319.CrossRefGoogle ScholarPubMed
23. Pahl, E, Naftel, D, Canter, C, Frazier, E, Kirklin, J, Morrow, W. Death after rejection with severe hemodynamic compromise in pediatric heart transplant recipients: a multi-institutional study. J Heart Lung Transplant 2001; 20: 279–287.CrossRefGoogle ScholarPubMed
24. Everitt, M, Pahl, E, Schechtman, K. Rejection with hemodynamic compromise in the current era of pediatric heart transplantation: a multi-institutional study. J Heart Lung Transplant 2010; 30: 282–288.CrossRefGoogle ScholarPubMed
25. Webber, S, Naftel, D, Parker, J. Late rejection episodes more than 1 year after pediatric heart transplantation: risk factors and outcomes. J Heart Lung Transplant 2003; 22: 869–875.CrossRefGoogle ScholarPubMed
26. Ameduri, R, Zheng, J, Schechtman, K. Has late rejection decreased in pediatric heart transplantation in the current era? A multi-institutional study. J Heart Lung Transplant 2012; 31: 980–986.CrossRefGoogle Scholar
27. Gossett, J, Canter, C, Zheng, J, et al. Decline in rejection in the first year after pediatric cardiac transplantation: a multi-institutional study. J Heart Lung Transplant 2010; 29: 625–632.CrossRefGoogle ScholarPubMed
28. Chin, C, Naftel, D, Singh, T, et al. Risk factors for recurrent rejection in pediatric heart transplantation: a multicenter experience. J Heart Lung Transplant 2004; 23: 178–185.CrossRefGoogle ScholarPubMed
29. Boucek, R, Naftel, D, Boucek, M, et al. Induction immunotherapy in pediatric heart transplant recipients: a multi-center evaluation. J Heart Lung Transplant 1999; 18: 460–469.CrossRefGoogle Scholar
30. Gajarski, R, Blume, E, Urshel, S, et al. Infection and malignancy after pediatric heart transplantation: the role of induction therapy. J Heart Lung Transplant 2011; 30: 299–308.CrossRefGoogle ScholarPubMed
31. Schowengerdt, K, Naftel, D, Seib, P, et al. Infection after pediatric heart transplantation: results of a multi-institutional study. J Heart Lung Transplant 1997; 16: 1207–1216.Google Scholar
32. George, J, Taylor, D, Blume, E, et al. Minimizing infection and rejection death: clues acquired from 19 years of multi-institutional cardiac transplantation data. J Heart Lung Transplant 2011; 30: 151–157.CrossRefGoogle Scholar
33. Webber, S, Naftel, D, Fricker, F, et al. Lymphoproliferative disorders after paediatric heart transplantation: a multi-institutional study. Lancet 2006; 367: 233–239.CrossRefGoogle ScholarPubMed
34. Pahl, E, Naftel, D, Kuhn, M, et al. The impact and outcome of transplant coronary artery disease in a pediatric population: a 9 year multi-institutional. J Heart Lung Transplant 2005; 24: 645–651.CrossRefGoogle Scholar
35. Feingold, B, Zheng, J, Law, Y, et al. Risk factors for late renal dysfunction after pediatric heart transplantation: a multi-institutional study. Pediatr Transplant 2011; 15: 699–705.CrossRefGoogle ScholarPubMed