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Mid-term aortic valve outcomes after surgical repair of doubly committed subarterial ventricular septal defect

Published online by Cambridge University Press:  25 September 2025

Zhuheng Wu ,
Lin Xie ,
Jingyu Liu ,
Yanlin Yang ,
Yajiao Li ,
Changping Gan ,
Hong Qian  and
Ke Lin Open the ORCID record for Ke Lin [Opens in a new window]
Zhuheng Wu
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
Lin Xie
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
Jingyu Liu
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
Yanlin Yang
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
Yajiao Li
Affiliation:
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
Changping Gan
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
Hong Qian
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
Ke Lin*
Affiliation:
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China
*
Corresponding author: Ke Lin; Email: edidian@163.com.
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Abstract

Background:

Data on aortic valve outcomes following surgical repair of doubly committed subarterial ventricular septal defect remain limited.

Methods:

This retrospective study included doubly committed subarterial ventricular septal defect patients who underwent surgical repair at our centre from 2013 to 2023. The primary outcome was the incidence of new-onset aortic regurgitation during follow-up.

Results:

A total of 320 patients were included, with a median age of 2.0 (0.9–7.2) years. Among them, 289 patients underwent surgical repair alone (repair group), and 31 received additional aortic valve surgery (repair + aortic valve surgery group). Preoperatively, 58 (18.1%) patients exhibited aortic regurgitation ≥ mild (10.7% in the repair group vs 87.1% in the repair + aortic valve surgery group, P < 0.001). The overall median follow-up was 40.5 (16.0–72.0) months. At the last follow-up, 23 (7.4%) patients had aortic regurgitation ≥ mild (3.8 vs 52.2%, P < 0.001), and 6 (1.9%) had aortic regurgitation > mild (0.3 vs 21.7%, P < 0.001). Sixteen (5.1%) patients developed new-onset aortic regurgitation during follow-up (1.7 vs 47.8%, log-rank P < 0.001), and 6 (1.9%) of them developed new-onset aortic regurgitation > mild (0.3 vs 21.7%, log-rank P < 0.001). Age, ventricular septal defect size, preoperative aortic regurgitation > mild, and maximum aortic valve flow velocity (AVmax) were related to concurrent aortic valve surgery and new-onset aortic regurgitation.

Conclusions:

Based on our retrospective data, the mid-term aortic valve outcomes after doubly committed subarterial ventricular septal defect repair were relatively satisfactory, with a low incidence of new-onset aortic regurgitation during follow-up. However, aortic valve outcomes for patients who received concurrent aortic valve surgery were less satisfactory.

Keywords

Doubly committed subarterial ventricular septal defectaortic valvesurgical repairmid-term outcomes

Information

Type
Original Article
Information
Cardiology in the Young , First View , pp. 1 - 8
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Copyright
© The Author(s), 2025. Published by Cambridge University Press

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Footnotes

†

Zhuheng Wu and Lin Xie shared the first authorship.

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