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Absence of association of FCGR2A gene polymorphism rs1801274 with Kawasaki disease in Greek patients

Published online by Cambridge University Press:  28 April 2014

Anthoula Chatzikyriakidou ,
Louiza Aidinidou ,
Andreas Giannopoulos ,
Kyriaki Papadopoulou-Legbelou ,
Kallirhoe Kalinderi  and
Liana Fidani
Anthoula Chatzikyriakidou
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
Louiza Aidinidou
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
Andreas Giannopoulos
Affiliation:
2nd Department of Pediatric, Pediatric Cardiology Clinic, Ahepa University Hospital, Aristotle University of Thessaloniki, Greece
Kyriaki Papadopoulou-Legbelou
Affiliation:
4th Department of Paediatrics, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece
Kallirhoe Kalinderi
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
Liana Fidani*
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
*
Correspondence to: L. Fidani, Department of General Biology, Medical School, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece. Tel.: +30 2310999165; Fax: +30 2310999019; E-mail: lfidani@med.auth.gr
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Abstract

Kawasaki disease is an acute, febrile syndrome in infancy, characterised by vasculitis of medium-sized arteries, and affects predominantly young children. Family-based studies on Kawasaki disease supports the contribution of genetic factors in disorder manifestation. In a recent genome-wide association study, the polymorphism rs1801274 of FCGR2A [Fc fragment of immunoglobulin G, low-affinity IIa, receptor] gene has been implicated in disease pathogenesis. The aim of the present study was to explore the association of this variant, for the first time, in a group of Kawasaki-diseased patients of Greek origin. A total of 47 Kawasaki-diseased children and 50 control subjects were enrolled in the study. Polymerase chain reaction–restriction fragment length polymorphism assay was performed in rs1801274 genotyping. No association was observed between this polymorphism genotypes’ or alleles’ distribution between Kawasaki-diseased patients and controls. Furthermore, no association was revealed between this polymorphism and cardiovascular complications in Kawasaki-diseased patients. In the literature, the reported data over this polymorphism association with Kawasaki disease in Caucasian patients are contradictory. In addition, the disease shows low prevalence in the Caucasian populations. Therefore, the independent genetic association studies on rs1801274 with Kawasaki disease in various Caucasian groups increase the amount of genetic data, which could be used in a future meta-analysis, increasing the statistical power of the resultant conclusions.

Keywords

Kawasaki diseaseFCGR2A genepolymorphism

Information

Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 4 , April 2015 , pp. 681 - 683
Copyright
© Cambridge University Press 2014 

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References

1. Kawasaki, T, Kosaki, F, Okawa, S, et al. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics 1974; 54: 271–276.Google Scholar
2. Fimbres, AM, Shulman, ST. Kawasaki Disease. Pediatr Rev 2008; 29: 308–316.Google Scholar
3. Burns, JC, Glode, MP. Kawasaki syndrome. Lancet 2004; 364: 533–544.CrossRefGoogle ScholarPubMed
4. Nakamura, Y, Yashiro, M, Uehara, R, et al. Epidemiologic features of Kawasaki disease in Japan: results of the 2009–2010 nationwide survey. J Epidemiol 2012; 3: 216–221.CrossRefGoogle Scholar
5. Fujita, Y, Nakamura, Y, Sakata, K, et al. Kawasaki disease in families. Pediatrics 1989; 84: 666–669.Google Scholar
6. Uehara, R, Yashiro, M, Nakamura, Y, et al. Kawasaki disease in parents and children. Acta Paediatr 2003; 92: 694–697.Google Scholar
7. Uehara, R, Yashiro, M, Nakamura, Y, et al. Clinical features of patients with Kawasaki disease whose parents had the same disease. Arch Pediatr Adolesc Med 2004; 158: 1166–1169.Google Scholar
8. Lv, YW, Wang, J, Sun, L, et al. Understanding the pathogenesis of Kawasaki disease by network and pathway analysis. Comput Math Methods Med 2013, doi:10.1155/2013/989307.Google Scholar
9. Khor, CC, Davila, S, Breunis, WB, et al. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet 2011; 43: 1241–1246.CrossRefGoogle ScholarPubMed
10. Warmerdam, PA, van de Winkel, JG, Vlug, A, et al. A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 1991; 147: 1338–1343.Google Scholar
11. Falcini, F, Trapani, S, Turchini, S, et al. Immunological findings in Kawasaki disease: an evaluation in a cohort of Italian children. Clin Exp Rheumatol 1997; 15: 685–689.Google Scholar
12. Biezeveld, M, Geissler, J, Merkus, M, et al. The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease. Clin Exp Immunol 2007; 147: 106–111.Google Scholar
13. Shrestha, S, Wiener, H, Shendre, A, et al. Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response. Circ Cardiovasc Genet 2012; 5: 309–316.Google Scholar