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Valproic Acid Producing a Reye-Like Syndrome

Published online by Cambridge University Press:  18 September 2015

D. L. Keene ,
P. Humphreys ,
B. Carpenter  and
J.P. Fletcher
D. L. Keene
Affiliation:
the Children’s Hospital of Eastern Ontario, Ottawa, Ontario
P. Humphreys
Affiliation:
the Children’s Hospital of Eastern Ontario, Ottawa, Ontario
B. Carpenter
Affiliation:
the Children’s Hospital of Eastern Ontario, Ottawa, Ontario
J.P. Fletcher
Affiliation:
the Children’s Hospital of Eastern Ontario, Ottawa, Ontario
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Although several cases of acute hepatic failure associated with the administration of valproic acid (VPA) have been reported, the pathogenesis of this problem remains unclear. We report the case of a 40 month old male with a chronic seizure disorder treated with VPA and phenytoin for two years, who developed sudden progressive neurological deterioration with evidence of increased intracranial pressure and hepatic failure. The clinical features closely resembled those of Reye’s syndrome suggesting the possibility of a common pathogenesis.

Information

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 4 , November 1982 , pp. 435 - 437
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

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