Hostname: page-component-54dcc4c588-ff9ft Total loading time: 0 Render date: 2025-10-11T09:36:39.524Z Has data issue: false hasContentIssue false
  • English
  • Français

Treatment of Experimental Allergic Neuritis With Prednisolone

Published online by Cambridge University Press:  18 September 2015

T.E. Feasby ,
J.J. Gilbert ,
A.F. Hahn  and
D.S. Lovgren
J.J. Gilbert
Affiliation:
Department of Clinical Neurological Sciences and the Department of Pathology, University of Western Ontario, London
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Experimental allergic neuritis (EAN) in Lewis rats was treated with prednisolone given prophylactically or therapeutically. Rats treated from the time of immunization with myelin or after the establishment of clinical disease improved more rapidly than controls. Treatment at the onset of clinical signs resulted in less severe disease and more rapid recovery. Rats treated just prior to the onset of clinical signs (day 10) did not develop significant clinical disease and appeared to have less inflammation in their nerves and nerve roots on microscopic examination.

Information

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue 1 , February 1987 , pp. 46 - 49
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

1.Arnason, BG.Acute inflammatory demyelinating polyradiculopathies. In: Dyck, P, Thomas, P, Lambert, E, Bunge, R, eds. Peripheral Neuropathy, Philadelphia: W.B. Saunders Co. 1984; 2050–2100.Google Scholar
2.Dyck, PJ, Arnason, BG.Chronic inflammatory demyelinating Polyradiculoneuropathies. In: Dyck, P, Thomas, P, Lambert, E, Bunge, R, eds. Peripheral Neuropathy, Philadelphia: W.B. Saunders Co. 1984; 2101–2114.Google Scholar
3.Hughes, RAC, Kadlubowski, M, Hufschmidt, A.Treatment of Acute Inflammatory Polyneuropathy. Ann Neurol 9 (Suppl) 1981; 125–133.Google Scholar
4.King, RHM, Craggs, Rl, Gross, MLP and Thomas, PK.Effects of Glucocorticoids on Experimental Allergic Neuritis. Experimental Neurology 1985; 87: 9–19.Google Scholar
5.Norton, WT, Poduslo, SE.Myelination in rat brain-changes in myelin composition during brain maturation. J Neurochem (1973); 21: 759–773.Google Scholar
6.Kadlubowski, M, Hughes, R, Gregson, N.Experimental allergic neuritis in the Lewis rat-characterization of the activity of peripheral myelin and its major basic protein, P2. Brain Res 1980; 184: 439–454.Google Scholar
7.Tansey, F, Brosnan, C.Protection against experimental allergic neuritis with silicaquartzdust. J Neuroimmunol 1982; 3: 168–179.Google Scholar
8.Dowling, PC, Bosch, VV, Cook, SD.Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis. Neurology 1980; 30: 33–36.Google Scholar
9.Hughes, RAC, Newsom-Davis, J, Perkin, GD, Pierce, JM.Controlled trial of prednisolone in acute polyneuropathy. Lancet 1978; 2: 750–753.Google Scholar
10.Hahn, AF, Feasby, TE, Gilbert, JJ.Blood-Nerve barrier studies in Experimental Allergic Neuritis. Acta Neuropathol (Berl) 1985; 68: 101–109.Google Scholar
11.Rinehart, JJ, Sagone, AL, Balcerzak, SP, Ackerman, GA, LoBuglio, AF.Effects of Corticosteroid Therapy on Human Monocyte Function. New England J Med 1975; 292: 236–241.Google Scholar
12.Lampert, PW.Mechanism of Demyelination in Experimental Allergic Neuritis. Electron Microscope Studies. Lab Investigations 1969; 20: 127–138.Google Scholar
13.Cammer, W, Bloom, BR, Norton, WT, Gordon, AD.Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages — a possible mechanism of inflammatory demyelination. Proc Nat Acad Sci (U.S. A.) 1978; 75: 1554–1558.Google Scholar
14.Werb, PZ.Biochemical actions of glucocorticoids on macrophages in culture. Specific Inhibition of Elastase, Collagenase, and Plasminogen Activator Secretion and effects on other metabolic functions. J Exp Med 1978; 147: 1695–1712.Google Scholar
15.Sobue, G, Yamato, S, Hirayama, M, Matsuoka, Y, Uematsu, H, Sobue, I.The role of macrophages in demyelination in experimental allergic neuritis. J Neurol Sc 1982; 56: 75–87.Google Scholar
16.Schuyler, MR, Gerblich, A, Vida, C.Prednisone and T-Cell Subpopulations. Arch lnt Med 1984; 144: 973–975.Google Scholar
17.Hedman, LA, Rockert, LL, Lundin, PM.The effect of steroids on the circulating lymphocyte population VI: studies on the thoracic duct T- and B-lymphocyte populations alter neonatal thymectomy and prednisolone treatment. An immunofluorescence study in the rat. Int J Immunopharmacology 1984; 6: 357–363.Google Scholar
18.Bast, RC Jr, Reinherz, EL, Maver, C, Lavin, P, Schlossman, SF.Contrasting effects of cyclophosphamide and prednisolone on the phenotype of human peripheral blood leukocytes. Clinical Immunology and lmmunopathology 1983; 28: 101–114.Google Scholar
19.ten Berge, RJM, Sawerwein, HP, Yong, SL, Schellekens, PThA.Administration of Prednisolone in vivo affects the ratio of OKT4/OK.T8 and the LDH-enzyme pattern of Human T Lymphocytes. Clinical Immunology and lmmunopathology 1984; 30: 91–103.Google Scholar
20.Claman, HN.Corticosteroids and lymphoid cells. New England J Med 1972; 287: 88–397.Google Scholar
21.Hughes, RAC, Kadlubowski, M, Gray, IA, Leibowitz, S.Immune responses in experimental allergic neuritis. J Neurology Neurosurgery and Psychiatry 1981b; 44: 565–569.Google Scholar
22.Linington, C, Izumo, S, Suzuki, M, Uyemura, K, Meyermann, R, Wekerle, H.A permanent rat-T-cell line that mediates experimental allergic neuritis in the Lewis rat in viv. J Immunol 1984; 133: 1946–1950.Google Scholar
23.Izumo, S, Linington, C, Wekerle, H and Meyermann, R.Morphologic Study on Experimental Allergic Neuritis Mediated by T Cell Line Specific for Bovine P2 protein in Lewis rats. Laboratory Investigation 1985b; 53: 209–218.Google Scholar
24.Holmdahl, R, Olsson, T, Moran, T, Klareskog, L. In vivo Treatment of rats with monoclonal anti-T-cell antibodies. Immunohistochemical and functional analysis in normal rats and in experimental allergic neuritis. Scand J Immunol 1985b; 22: 157–169.Google Scholar
25.Swick, HM, McQuillen, MP.The use of steroids in the treatment of idiopathic polyneuritis. Neurology (Minneop.) 1976; 26: 205–212.Google Scholar
26.Dalakas, MC, Engel, WK.Chronic relapsing (dysimmune) polyneuropathy: pathogenesis and treatment. Ann Neurol 1981; 9 (Suppl): 134–145.Google Scholar
27.Dyck, PJet al.Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. Ann Neurol 1982; 11: 136–141.Google Scholar