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Regulation of Brain Pyruvate Dehydrogenase Multienzyme Complex

Published online by Cambridge University Press:  18 September 2015

T.T. Ngo  and
A. Barbeau
T.T. Ngo
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine AvenueWest, Montreal, Quebec, Canada H2W 1R7.
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A number of excellent and comprehensive reviews on various aspects of pyruvate dehydrogenase multienzyme complex have been written recently. The purpose of the present review is to summarize briefly the reaction mechanism and the regulation of this enzyme. Emphasis is put on the most recent literature not covered by previous reviews. Particular attention is also paid to the regulation of brain pyruvate dehydrogenase multienzyme complex, since a number of patients with neuromuscular diseases, such as Friedreich's ataxia, show a decreased rate of pyruvate oxidation.

Information

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 2 , May 1978 , pp. 231 - 238
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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