Background: Surgical access to the clival region is challenging, but advanced endoscopic endonasal approaches (EEA) provide a minimally invasive corridor. This study aimed to review the clinical outcomes of patients who underwent EEA for skull base lesions involving the clivus and to analyze prognostic factors. Methods: A retrospective review was conducted of patients who underwent EEA for resection of clival lesions between October 2001 and October 2023. Data on demographics, approach type, reconstruction technique, tumor pathology and outcomes were collected. Results: Forty-six patients underwent transclival EEA. The majority had ASA scores II and III (71.7%), with clival chordomas being the most common pathology (37%). Cranial nerve impairment was present in 65% of patients, and 80% showed improvement post-surgery. The mean procedure duration was 308 minutes, with a mean blood loss of 424 mL. A lumbar drain was used in 10.9%, and 76.1% received a pedicled nasoseptal flap for reconstruction. Complete tumor resection was achieved in 74% of malignant cases. Postoperative CSF leaks occurred in 4.3%, and the mean length of stay was 12.2 days. Higher readmission rates were associated with ASA IV classification (p=0.006). Conclusions: EEA to the clival region is safe and effective, with low perioperative complications and high rates of postoperative improvement.