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Published online by Cambridge University Press: 10 July 2025
Background: Facial diplegia with paresthesias (FDP) is a rare Guillain-Barré Syndrome (GBS) variant, characterized by subacute onset of bilateral facial palsy with no other motor weakness, absent reflexes and distal paresthesias, that may be associated with anti-ganglioside autoantibodies. Methods: Patient chart, including medical notes, radiologic, electrophysiological and laboratory testing during the patient’s hospitalization in December 2024 were reviewed. Results: We report the case of a 24-year-old woman, who presented one-week post-partum with a history of tongue and progressive distal extremity paresthesias, headache and gait instability. During hospitalization patient progressively developed bilateral lower limbs areflexia and facial diplegia. Imaging was negative for a central cause but lumbar puncture and clinical examination guided the diagnosis of FDP. Patient responded to a course of intravenous immunoglobulins (IVIg) and was discharged home without any weakness. Conclusions: This case illustrates the rarer FDP presentation of GBS, which can be more frequent in the postpartum period, and explores the differential diagnosis of subacute facial diplegia.