Hostname: page-component-cb9f654ff-r5d9c Total loading time: 0 Render date: 2025-09-07T07:35:55.184Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic Linkage of the Huntington’s Disease Gene to a DNA Marker

Published online by Cambridge University Press:  18 September 2015

James F. Gusella
James F. Gusella*
Affiliation:
the Neurology Service and Genetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts
*
Genetics Unit, Massachusetts General Hospital, Boston, Ma. 02114, U.S.A.
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Recombinant DNA techniques have provided the means to generate large numbers of new genetic linkage markers. This technology has been used to identify a DNA marker that coinherits with the Huntington’s Disease (HD) gene in family studies. The HD locus has thereby been mapped to human chromosome 4. The discovery of a genetic marker for the inheritance of HD has implications both for patient care and future research. The same approach holds considerable promise for the investigation of other genetic diseases, including Dystonia Musculorum Deformans.

Information

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 421 - 425
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Botstein, D., White, RL., Skolnick, M., Davis, R. (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. 32: 314–331.Google ScholarPubMed
Chase, TN., Wexler, NS., Barbeau, A., eds (1979) Huntington’s disease. Adv. Neurol. 23 (Raven Press, New York).Google Scholar
Gusella, JF., Wexler, NS., Conneally, PM., et al. (1983) A polymorphic DNA marker genetically linked to Huntington’s disease. Nature 306: 234–238.CrossRefGoogle ScholarPubMed
Gusella, JF., Tanzi, R., Anderson, MA., et al. (1983) In: Banbury Report 14: “Recombinant DNA applications to human disease” C.T. Caskey, R.L. White eds. The use of restriction fragment length polymorphisms to map the Huntington’s disease gene. (Cold Spring Harbor, New York) pp. 261–266.Google Scholar
Hayden, MR. (1981) Huntington’s Chorea (Springer, New York).CrossRefGoogle ScholarPubMed
Housman, D., Gusella, JF. (1982) In: “Molecular Genetic Neuroscience” Schmitt, F.O.Bird, S.J.Bloom, F.E. eds. (Raven, New York) pp. 415–424. Molecular genetic approaches to neural degenerative disorders.Google Scholar
Housman, D., Gusella, J. (1981) In “Genetic Strategies for Psychobiology and Psychiatry”, Gershon, E.S.Matthysse, S.Breakfield, X.O.Ciaranello, R.D. eds. (Boxwood). Use of recombinant DNA techniques for linkage studies in genetically based neurological disorders.Google Scholar
Huntington, G. (1972) Med. Surg. Reporter 26: 317–321.Google Scholar
Ott, J. (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am. J. Hum. Gen. 26: 588–597.Google ScholarPubMed
Pericak-Vance, MA., Conneally, PM., Merritt, AD., et al. (1979) Genetic linkage in Huntington’s disease. Adv. Neurol. 23: 59–72.Google Scholar
Southern, EM. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 503–517.CrossRefGoogle ScholarPubMed
Went, LN., Volkers, WS. (1979) Genetic linkage. Adv. Neurol. 23: 37–42.Google Scholar