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Effects of Glutamate and Aspartate on Ataxic Gait Induced by 3-Acetyl Pyridine in Rats

Published online by Cambridge University Press:  18 September 2015

G. De Michele ,
F.B. Jolicoeur ,
D.B. Rondeau ,
R.F. Butterworth  and
A. Barbeau
G. De Michele
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
F.B. Jolicoeur
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
D.B. Rondeau
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
R.F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Ave. West, Montreal, Québec, Canada H2W 1R7
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The main purpose of this study was to examine the effects of intraventricular injections of glutamate and aspartate on the walking gait of rendered ataxic by the administration of 3-acetyl pyridine. Both amino acids significantly improved the walking gait of these animals. The effects of other substances known to have a stimulatory influence on locomotor activity in rats were also investigated. Amphetamine, apomorphine and thyrotropin releasing hormone (TRH) had no effect on the ataxic gait of 3-AP treated animals. Substance P significantly improved the gait of ataxic animals, but to a lesser extent than that seen with glutamate and aspartate.

Information

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 451 - 454
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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