Background: Computed tomography (CT) is common imaging modality, though its utilization of iodinated contrast media (ICM) has been historically associated with adverse effects on the kidneys including nephropathy. This study aims to investigate whether administration of ICM in critically ill patients is associated with reduced kidney function and acute kidney injury (AKI). Methods: Data was used from two prospective cohort studies- ACT-TBI and CANCCAP, where patients underwent a whole head CT perfusion with additional CT scans. Serum creatinine (CR) and glomerular filtration rate (eGFR) were sequentially collected for five days of their ICU stay. AKI was evaluated following the KDIGO criteria. Results: Of the 291 patients enrolled, a stratified trend analysis for eGFR could be conducted in 158 patients. No AKI was identified in any of these patients in our study. A significant upward trend in eGFR was observed in those older than 40 years (p=0.027), those with hypertension (p=0.027), diabetes (p=0.027) and history of smoking (p=0.027), The volume of ICM received was not significantly associated with patients’ eGFR. Conclusions: AKI was not identified in critically ill patients who received ICM but significant upward trend of eGFR was seen in older individuals and those with diabetes, hypertension, and a history of smoking.