Background: Epilepsy has significant implications to quality of life (QOL) beyond the seizures themselves. While research has investigated QOL among people with epilepsy (PwE) from around the globe, minimal research exists on QOL among PwE living in Canada. Methods: People with drug-resistant epilepsy admitted to the Epilepsy Monitoring Unit in London, Ontario completed the “Quality of Life in Neurological Disorders” questionnaire (Neuro-QOL), a scale evaluating 13 QOL domains. We assessed objective cognition using a battery called Creyos. Results: Participants (N=42) scored significantly worse than the reference populations on the anxiety, satisfaction with social roles and activities, and cognitive functioning Neuro-QOL domains (p<.05). Scores on these domains, as well as depression and positive affect/well-being were unrelated to age (mean=39.3 years, SD=16.9), sex (28 females), education level, epilepsy duration, and age of epilepsy onset (p>.05). There were no correlations between scores on these Neuro-QOL domains and Creyos performance in short-term memory, reasoning, and verbal processing (p>.05). Conclusions: PwE living in Canada experience negative QOL in anxiety, social satisfaction, and subjective cognition, unrelated to the clinical factors or cognitive domains investigated. More attention is needed in Canadian clinical care and research to assess and address these affected attributes of QOL for all PwE.