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Cytoplasmic Tubular Aggregates and Nuclear Filamentous Bodies in Two Suspected Cases of Viral Encephalitis

Published online by Cambridge University Press:  18 September 2015

Dikran S. Horoupian ,
R.T. Ross ,
Mark J. Gurwith  and
Jan Hoogstraten
Dikran S. Horoupian*
Affiliation:
Department of Pathology and Medicine Health Sciences Centre and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
R.T. Ross
Affiliation:
Department of Pathology and Medicine Health Sciences Centre and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Mark J. Gurwith
Affiliation:
Department of Pathology and Medicine Health Sciences Centre and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Jan Hoogstraten
Affiliation:
Department of Pathology and Medicine Health Sciences Centre and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
*
Neuropathology Unit, Department of Pathology, Health Sciences Centre, 700 William Avenue, Winnipeg, Manitoba R3E 0Z3 Canada
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Summary

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Two suspected cases of viral encephalitis are presented. Viral nucleocapsids were not seen, but cytoplasmic paramyxovirus-like aggregates and nuclear filamentous bodies were frequently encountered. Both structures were seen in the same cell. Contrary to other reports, the cytoplasmic aggregates were mostly observed in hematogenous mononuclear cells, less frequently in neuronal cell elements and rarely in endothelial cells. The non-specific nature of these structures is emphasized.

Information

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 1 , Issue 2 , May 1974 , pp. 98 - 105
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

References

Anzil, A.P. and Blinzinger, K. (1972) Electron microscopic studies of rabbit central and peripheral nervous system in experimental Borna disease. Acta Neuropathologica (Berl.) 22, 305–18.CrossRefGoogle ScholarPubMed
Baringer, J.R. (1971) Tubular aggregates in endoplasmic reticulum in herpes simplex encephalitis. New England Journal of Medicine 285, 943–5.CrossRefGoogle ScholarPubMed
Baringer, J.R. and Griffith, J.F. (1970) Experimental herpes simplex encephalitis: early neuropathologic changes. Journal of Neuropathology and Experimental Neurology 29, 89–104.CrossRefGoogle ScholarPubMed
Baringer, J.R. and Swoveland, P. (1972) Tubular aggregates in endoplasmic reticulum. Evidence against their viral nature. Journal of Ultrastructural Research 41, 270–6.CrossRefGoogle ScholarPubMed
Blinzinger, K., Simon, J., Magrath, D. and Boulger, L. (1969) Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord. Science 163, 1336–7.CrossRefGoogle ScholarPubMed
Brown, J.W., Kotorii, K. andRiehl, J.L. (1968) Ultrastructural studies in myoclonus epilepsy (Clinical Unverricht-Lafora’s disease). Neurology 18, 427–38.CrossRefGoogle ScholarPubMed
CENTER FOR DISEASE CONTROL “Annual Encephalitis Summary - 1970”, Jan. 1972. DHEW Publication No. (HSM) 72–8093.Google Scholar
Chandra, S. (1968) Undulating tubules associated with endoplasmic reticulum in pathologic tissues. Laboratory Investigation 18, 422–8.Google ScholarPubMed
Cohen, E. B. and Pappas, G.D. (1969) Dark profiles in the apparently normal central nervous system: a problem in the electron microscopic identification of early anterograde axonal degeneration. Journal of Comparative Neurology 136, 375–96.CrossRefGoogle ScholarPubMed
Dupuy-Coin, A.M. and Bouteille, M. (1972) Developmental pathway of granular and beaded nuclear bodies from nucleoli. Journal of Ultrastructural Research 40, 55–67.CrossRefGoogle ScholarPubMed
Feldman, M.L. and Peters, A. (1972) Intranuclear rods and sheets in rat cochlear nucleus. Journal of Neurocytology 1, 109–27.CrossRefGoogle ScholarPubMed
Gyorkey, F., Min, K.W., Sinkovics, J.G. and Gyorkey, P. (1969) Systemic lupus erythematous and myxovirus. New England Journal of Medicine 280, 333.Google Scholar
Haas, J.E. and Yunis, E.J. (1970) Tubular inclusions of systemic lupus erythematosus. Ultrastructural observations regarding their possible viral nature. Experimental and Molecular Pathology 12, 257–63.CrossRefGoogle Scholar
Hadfield, M.G., David, R.B. and Rosenblum, W.I. (1972) Coiled nucleocapsid configuration in subacute sclerosing panencephalitis (SSPE). Acta Neuropathologica (Berl.) 21, 263–71.CrossRefGoogle Scholar
Herndon, R.M. and Rubinstein, L.J. (1968) Light and electron microscopy observations on the development of viral particles in the inclusions of Dawson’s encephalitis (subacute sclerosing panencephalitis). Neurology 18, Part 2, 8–20.CrossRefGoogle ScholarPubMed
Hodges, G.R., Fass, R.I. and Saslaw, S. (1972) Central nervous system disease associated with mycoplasma pneumoniae infections. Archives of Internal Medicine 130, 277–82.CrossRefGoogle Scholar
Landry, M. and Winkelmann, R.K. (1972) Tubular cytoplasmic inclusion in dermatomyositis. Mayo Clinic Proceedings 47, 479–92.Google ScholarPubMed
Masurovsky, E.B., Bunge, M.B. and Bunge, R.P. (1967) Cytological studies of organotypic cultures of rat dorsal root ganglia following X-irradiation in-vitro, I. Changes in neurons and satellite cells. Journal of Cell Biology 32, 467–96.CrossRefGoogle ScholarPubMed
Murphy, F.A., Harrison, A.K., Gary, G.W. Jr., Whitfield, S.G. and Forrester, F.T. (1968) St. Louis encephalitis virus infection of mice: electron microscopic studies of central nervous system. Laboratory Investigation 19, 652–62.Google ScholarPubMed
Oyanagi, S., Müller, D., Ter Meulen, V., Katz, M. and Koprowski, H. (1970) Electron microscopic observations in subacute sclerosing pan-encephalitis brain cell cultures; their correlation with cytochemical and immunocytologic findings. Journal of Virology 6, 370–9.CrossRefGoogle Scholar
Perier, O. and Vanderhaeghen, J.J. (1966) Indications étiologiques apportées par la microscopie electronique dans certaines encephalites humaines. Revue Neurologique 115, 250–4.Google Scholar
Peters, A., Palay, S.L. and Webster, H. (1970) The fine structure of the nervous system. New York: Harper and Row, 42–3.Google Scholar
Robertson, D.M. and Maclean, J.D. (1965) Nuclear inclusions in malignant gliomas. Archives of Neurology 13: 287–96.CrossRefGoogle ScholarPubMed
Robertson, D.M. (1964) Electron microscope studies of nuclear inclusions in meningiomas. American Journal of Pathology 45, 835–48.Google ScholarPubMed
Tommasi, M., Berard-Badier, M., Toga, M., and Vedrenne, C. (1970) Maladies virales du système nerveu. Annates d’Anatomie Pathologique 15, 129–52.Google Scholar
Uzman, B.G., Saito, H. and Kasac, M. (1971) Tubular arrays in the endoplasmic reticulum in human tumor cells. Laboratory Investigation 24, 492–8.Google ScholarPubMed
Zu Rhein, G.M. and Chou, S.M. (1968) Subacute sclerosing panencephalitis. Ultrastructural study of a brain biopsy. Neurology 18, Part 2, 146–60.CrossRefGoogle ScholarPubMed