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Urinary excretion of aflatoxin M1 after administration of aflatoxin B1 in sucrose- or starch-rich diets

Published online by Cambridge University Press:  09 March 2007

A. Wise ,
M. Suzangar ,
M. Messripour  and
J. Mohammadi
A. Wise
Affiliation:
Regional Mycotoxin Centre and Department of Biochemistry and Nutrition, University of Isfahan, Isfahan, Iran
M. Suzangar
Affiliation:
Regional Mycotoxin Centre and Department of Biochemistry and Nutrition, University of Isfahan, Isfahan, Iran
M. Messripour
Affiliation:
Regional Mycotoxin Centre and Department of Biochemistry and Nutrition, University of Isfahan, Isfahan, Iran
J. Mohammadi
Affiliation:
Regional Mycotoxin Centre and Department of Biochemistry and Nutrition, University of Isfahan, Isfahan, Iran
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Abstract

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1. Male Sprague–Dawley rats were given 630 g/kg sucrose or starch with 2 mg/kg aflatoxin B1 for periods of 75, 145 and 200 d, and the 24 h urinary excretion of aflatoxin M1 was measured.

2. Less aflatoxin M1 was excreted by the rats fed on the sucrose-rich diet compared to those fed on the starch-rich diet. This difference was especially marked when expressed per g metabolizing tissue.

3. It is concluded that sucrose probably decreases the activity of aflatoxin B1 metabolism in a similar way to its previously found effect on the drug-metabolizing enzyme.

Information

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 40 , Issue 2 , September 1978 , pp. 397 - 401
Copyright
Copyright © The Nutrition Society 1978

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