Hostname: page-component-54dcc4c588-hp6zs Total loading time: 0 Render date: 2025-10-12T15:04:27.479Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum thymic hormone activity in genetically-obese mice

Published online by Cambridge University Press:  09 March 2007

R. K. Chandra ,
Gloria Heresi  and
B. Au
R. K. Chandra
Affiliation:
Department of Pediatrics, Memorial University of Newfoundland, St John's, Newfoundland, Canada and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Gloria Heresi
Affiliation:
Department of Pediatrics, Memorial University of Newfoundland, St John's, Newfoundland, Canada and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
B. Au
Affiliation:
Department of Pediatrics, Memorial University of Newfoundland, St John's, Newfoundland, Canada and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Serum thymic hormone was assayed in genetically-obese (C57B1/6J ob/ob) mice and lean controls (+/+, +/−) of the same strain.

2. The thymic hormone activity was higher in the majority of the obese animals compared with non-obese mice.

3. The number of antibody-forming cells in the spleen expressed as a proportion of the total mononuclear cells was increased in the obese mice.

4. It is suggested that obesity is associated with significant changes in the thymic hormone levels which may alter the relative proportion of lymphocyte subsets and cell-mediated immunity.

Information

Type
Short Paper
Information
British Journal of Nutrition , Volume 45 , Issue 1 , January 1981 , pp. 211 - 213
Copyright
Copyright © The Nutrition Society 1981

References

Bach, J. F. & Dardenne, M. (1973). Immunology 25, 353.Google Scholar
Brent, L. & Holborow, J. (eds.) (1974). Prog. Immun. 2.Google Scholar
Chandra, R. K. (1975). Science, N.Y. 190, 289.CrossRefGoogle Scholar
Chandra, R. K. (1979). Clin. exp. Immun. 38, 228.Google Scholar
Chandra, R. K. (1980 a). Immunology of Nutritional Diporders. London: Edward Arnold.Google Scholar
Chandra, R. K. (1980 b). Am. J. clin. Nutr. 33, 13.CrossRefGoogle Scholar
Chandra, R. K., & Au, B. (1980). Int. Arch. Allergy Appl. Immunol. 61, 94.CrossRefGoogle Scholar
Chandra, R. K., & Newberne, P. M. (1977). Nutrition, Immunity and Infection: Mechanisms of Interactions. New York: Plenum.CrossRefGoogle Scholar
Dressor, D. W. & Wortis, H. H. (1966). Nature, Lond. 208, 859.CrossRefGoogle Scholar
Fiser, R. H., Rollins, J. B. & Biesel, W. R. (1975). Am. J. vet. Res. 33, 713.Google Scholar
Goldstein, G. (1977). In Progress in Immunology, vol. 3, p. 390 [Mandel, T. E., Cheers, C. and Hosking, C. S. editors]. New York: Elsevier.Google Scholar
Herberg, L. & Coleman, D. L. (1977). Metabolism 26, 59.CrossRefGoogle Scholar
Heresi, G. & Chandra, R. K. (1980). J. Nutr. (In the Press).Google Scholar
Meade, C. J., Sheena, J. & Mettin, J. (1979). Int. Arch. Allergy Appl. Immunol. 58, 121.CrossRefGoogle Scholar
Miller, J. F. A. P. (1972). Int. Rev. Cytol. 33, 77.CrossRefGoogle Scholar
Newberne, P. M. (1966). Fedn Proc. Fedn Am. Socs exp. Biol. 25, 1701.Google Scholar
Suskind, R. M. (ed.) (1977). Malnutrition and the Immune Response. New York: Raven.Google Scholar
van Bekkum, D. W. (ed.) (1975). The Biological Activity of Thymic Hormones. Rotterdam: Kooyker.Google Scholar