This chapter recounts some of the most important work that has been achieved or is ongoing: at global level (in the United Nations system); at regional level (especially in the African, American, and European human rights systems); by the International Committee of the Cross; and especially by pioneering civil society organizations (local and international human rights bodies). Thus, for instance, the seminal role of Amnesty International in promoting the adoption and implementation of a global treaty on the prohibition of torture—and drawing attention to the problem of torture more broadly—cannot be overstated.