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Applying statistical concepts to biological scenarios, this established textbook continues to be the go-to tool for advanced undergraduates and postgraduates studying biostatistics or experimental design in biology-related areas. Chapters cover linear models, common regression and ANOVA methods, mixed effects models, model selection, and multivariate methods used by biologists, requiring only introductory statistics and basic mathematics. Demystifying statistical concepts with clear, jargon-free explanations, this new edition takes a holistic approach to help students understand the relationship between statistics and experimental design. Each chapter contains further-reading recommendations, and worked examples from today's biological literature. All examples reflect modern settings, methodology and equipment, representing a wide range of biological research areas. These are supported by hands-on online resources including real-world data sets, full R code to help repeat analyses for all worked examples, and additional review questions and exercises for each chapter.
Applying statistical concepts to biological scenarios, this established textbook continues to be the go-to tool for advanced undergraduates and postgraduates studying biostatistics or experimental design in biology-related areas. Chapters cover linear models, common regression and ANOVA methods, mixed effects models, model selection, and multivariate methods used by biologists, requiring only introductory statistics and basic mathematics. Demystifying statistical concepts with clear, jargon-free explanations, this new edition takes a holistic approach to help students understand the relationship between statistics and experimental design. Each chapter contains further-reading recommendations, and worked examples from today's biological literature. All examples reflect modern settings, methodology and equipment, representing a wide range of biological research areas. These are supported by hands-on online resources including real-world data sets, full R code to help repeat analyses for all worked examples, and additional review questions and exercises for each chapter.
Using engaging prose, Mary E. Harrington introduces neuroscience students to the principles of scientific research including selecting a topic, designing an experiment, analyzing data, and presenting research. This new third edition updates and clarifies the book's wealth of examples while maintaining the clear and effective practical advice of the previous editions. New and expanded topics in this edition include techniques such as optogenetics and conditional transgenes as well as a discussion of rigor and reproducibility in neuroscience research. Extended coverage of descriptive and inferential statistics arms readers with the analytical tools needed to interpret data. Throughout, practical guidelines are provided on avoiding experimental design problems, presenting research including creating posters and giving talks, and using a '12-step guide' to reading scientific journal articles.
Using engaging prose, Mary E. Harrington introduces neuroscience students to the principles of scientific research including selecting a topic, designing an experiment, analyzing data, and presenting research. This new third edition updates and clarifies the book's wealth of examples while maintaining the clear and effective practical advice of the previous editions. New and expanded topics in this edition include techniques such as optogenetics and conditional transgenes as well as a discussion of rigor and reproducibility in neuroscience research. Extended coverage of descriptive and inferential statistics arms readers with the analytical tools needed to interpret data. Throughout, practical guidelines are provided on avoiding experimental design problems, presenting research including creating posters and giving talks, and using a '12-step guide' to reading scientific journal articles.
Most textbooks on regression focus on theory and the simplest of examples. Real statistical problems, however, are complex and subtle. This is not a book about the theory of regression. It is about using regression to solve real problems of comparison, estimation, prediction, and causal inference. Unlike other books, it focuses on practical issues such as sample size and missing data and a wide range of goals and techniques. It jumps right in to methods and computer code you can use immediately. Real examples, real stories from the authors' experience demonstrate what regression can do and its limitations, with practical advice for understanding assumptions and implementing methods for experiments and observational studies. They make a smooth transition to logistic regression and GLM. The emphasis is on computation in R and Stan rather than derivations, with code available online. Graphics and presentation aid understanding of the models and model fitting.
Most textbooks on regression focus on theory and the simplest of examples. Real statistical problems, however, are complex and subtle. This is not a book about the theory of regression. It is about using regression to solve real problems of comparison, estimation, prediction, and causal inference. Unlike other books, it focuses on practical issues such as sample size and missing data and a wide range of goals and techniques. It jumps right in to methods and computer code you can use immediately. Real examples, real stories from the authors' experience demonstrate what regression can do and its limitations, with practical advice for understanding assumptions and implementing methods for experiments and observational studies. They make a smooth transition to logistic regression and GLM. The emphasis is on computation in R and Stan rather than derivations, with code available online. Graphics and presentation aid understanding of the models and model fitting.